Pharmaceutical industries are changing their approach to drug discovery, the new in trend is bio-manufacturing based on bio-foundry model approach. Pharmaceutical industries has started to investing funds for establishing bio-manufacturing research & development lab. Let us understand what is the driving force? A fear of healthcare failure during the pandemic like COVID-19. Following the global spread of the SAR-CoV-2 virus, the pharmaceutical industry are currently undergoing significant changes. The world fell in need for a rapid response for immunizations, since the speed at which the new viral infection has spread, and the health disparities it has caused globally.
Also that with the advance technologies such as artificial intelligence (AI) machine learning, big data analytics, Knowledge base platform and robotics the process of drug discovery, clinical trials, personalized medicine and supply chain management have become faster, more efficient, much cost effective and environmentally sustainable. Advances in genomic and molecular biology have facilitated the development of targeted therapies also known as precision medicines e.g. CAR-T therapy against cancer. Biologics and gene therapies are medicines derived from the living organisms and offer targeted treatment option to various diseases like medicine as gene therapies involved modifying the patient’s genetic material to treat or prevent the diseases and has shown promising results in certain areas. Many Pharmaceutical industries are increasingly collaborating and becoming partners with the biotechnology firms, academic institutes and research organizations. By doing so they are pooling resources, expertise and knowledge, allowing faster development, shared risk, and the exploration of novel therapeutic approaches. Other than the points discussed above, there are areas undergoing massive changes such as regulatory environment which is becoming more approachable and flexible to meet the timely access of the breakthrough treatments. Also if we talk about the data and digital transformation, pharm industries are leveraging it to improve research, development and patient care as this enables more informed decision-making and the development of evidence-based therapies. Few of the above briefed changes happening in the pharmaceutical industry have the potential for long term sustainability. Let us start imagining that a bacteria can make the any and all the lifesaving medicines in most cost effective and sustainable manner.
Depending on the expansion of their economies, different regions and nations around the world accept innovations in the pharmaceutical industry at varying rates. The factors slowing down these changes in the pharmaceutical industry are the different regulatory environment across countries, diverse economic development, structure and complexity of healthcare systems around the world, cultural and social factors influencing the acceptance and adoption of these changes in pharmaceutical companies, generating more related skilled employment and difference in intellectual property regulations and market dynamics. A effort was made by 15 nonprofit biofoundries from all over the world gathered in London in June 2018 to discuss the creation of the Global Biofoundry Alliance (GBA). The alliance's goals were to promote teamwork, resource sharing, and common problems in the industry. Operations issues such sustainable development, high staff retention and infrastructure maintenance costs, small user bases, and a lack of knowledge regarding biofoundry capabilities were brought up at the discussion. The lack of standards for software, hardware, and methodology presented another difficulty by impeding interoperability and efficiency. The sharing of resources and intellectual property across borders raises legal difficulties. Despite these difficulties, it is acknowledged that the development of biofoundry capabilities is essential for nations to enhance their own capabilities in synthetic/engineered biology and realize its full potential.[1]
Let’s understand bio-foundry!
Bio-foundry is an establishment or advance lab. facility or pla...
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