The 2017 Access to Vaccines Index reveals the first landscape of industry activity to improve immunisation coverage. It finds a high level of diversity in how vaccine companies are improving access to vaccines for people living in poorer countries. This diversity is generally linked to the size of their portfolios and pipelines.
Vaccines are one of the most powerful and cost-effective health interventions available. Yet WHO states that an estimated 19.4 million infants worldwide are still missing out on basic vaccines.
"There is a world to be won by increasing access to vaccines," says Jayasree K Iyer, Executive Director, Access to Medicine Foundation. "As a global community, we all share the responsibility of ensuring everyone can benefit from immunisation. The companies that develop and manufacture vaccines clearly also have a role to play. This Index has mapped what vaccine companies are doing, and what prompts them to take action – it is a critical step in the effort to make vaccine markets more inclusive."
The independent index, analysed companies’ R&D pipelines, identifying nearly 90 vaccine projects for high-priority diseases. This includes dozens of first-ever vaccines, for diseases such as Ebola and a range of deadly bacterial infections. If successful, such vaccines could prove critical for tackling anti-microbial resistance (AMR). The Index also finds that companies are taking steps to prevent vaccine shortages and that, when setting prices, they all take affordability into account to a degree. All companies consider a country’s eligibility for support from Gavi, a public-private partnership that funds vaccine purchases for lower-income countries.
Governments are spending more on vaccines, including poorer countries. Many lower income countries procure vaccines with financial support from Gavi and through organisations such as UNICEF. The Index has mapped the actions of eight key vaccine companies, including the largest global players in terms of revenue. Often termed ‘the big four,’ GSK, Merck & Co, Pfizer and Sanofi represent around 80 per cent of global vaccine revenues. Serum Institute of India is also in scope. Serum Institute of India is of major importance for global public health, with a wide geographic reach and selling almost 1.4 billion vaccine doses each year. In addition to these five, the Index evaluates three further companies with significant potential for improving access to vaccines: Daiichi Sankyo, Johnson & Johnson and Takeda.
The Access to Vaccines Index measures company activity across defined sets of diseases and countries. The disease scope comprises 69 diseases with the highest priority for improving access to immunisation: including 44 diseases where no vaccines yet exist on the market, and 25 diseases where vaccines exist but with issues surrounding accessibility. The geographic scope comprises 107 countries with the highest perceived need for access to vaccines.
The index has examined company behaviour in three areas: research and development; pricing and registration; and manufacturing and supply. All eight companies were evaluated in research & development: here GSK leads, followed closely by Johnson and Johnson. Six of the companies (Daiichi Sankyo and Takeda are the exceptions) have vaccines on the market for diseases in scope and sales in countries in scope. These six companies were therefore suitable for evaluation in pricing and registration, and in manufacturing and supply. Across all three areas, GSK performs the best with Sanofi also performing well across the board.
In their vaccine portfolios and pipelines, the eight companies in scope concentrate on diseases with larger global markets: for example, the diseases with the most vaccines on the market are meningococcal disease, polio, seasonal influenza and hepatitis (A and B); the top five diseases targeted by R&D projects are pneumococcal disease, seasonal influenza, meningococcal disease, respiratory syncytial virus and human papillomavirus, which causes cervical cancer.
Vaccine companies are working on 89 vaccine R&D projects for 35 diseases. The most attention is given to pneumococcal disease, human papillomavirus and seasonal influenza. This focus largely corresponds to the presence of commercial incentives. A third of the projects in company pipelines target one...
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