Exscientia signed a 250 mn Euros deal with Sanofi in May. As part of this agreement, Exscientia will be responsible for all compound design, whilst chemistry synthesis will be delivered by Sanofi. With its unique AI platform, Exscientia is delivering a pipeline of efficacious, bispecific small molecules, as well as highly selective single target candidates, for multiple indications. Andrew Hopkins, CEO, Exscientia recently interacted with BioSpectrum on this
It’s estimated that, on average, to bring one new drug to the market can take 1,000 people, 12-15 years, and up to $1.6 billion. Pharmaceutical companies are grappling with these scandalous costs and constantly in search for inefficiencies in the drug discovery process, and hope to fasten the process by focusing on key elements, like management models, new technologies and creative study approaches. With many new viruses and bacteria daunting the globe there is an increased necessity to innovate and develop new drugs and safeguard public health. Also with patent cliff looming large, pharma companies need to evolve their R&D efforts to ensure that the core of their business keeps pace with the changes. With increasing competition, experts are looking at newer methods to speed up and increase accuracy rates. One such approach is using Artificial intelligence in drug discovery.
What is artificial intelligence (AI) and how does it speed up drug discovery process?
AI, if used correctly, is a new approach to drug discovery, that uses computer algorithms to search create original solutions to the questions a drug discovery scientist might ask when designing a new medicine. These systems are uniquely able to learn from existing data resources, much in the way that a human would learn and then apply the knowledge gained on a new project. However the amount of data now available is so vast that it is beyond a human’s capability. For AI focused towards drug design, where Exscientia focuses its expertise, the typical sources of information could be the vast resources of chemical structure, pharmacology, bioassays data as well as other supporting literature and patent information. The AI algorithms then apply the distillation to the design of new small molecules. Successful molecules will hit the desired target whilst at the same time avoiding known selectivity, toxicology or pharmokinetic issues (among many other parameters). Further refinement can lead to completely new and optimized molecules (and IP) for advancing towards the clinic. AI is also being applied to many areas of drug development. For example AI approaches might look at better patient stratification for clinical trials, thereby fitting the patient to the treatment being tested better, enabling quicker recruitment and increasing the likelihood of getting the required clinical response for regulatory approval.
What are the key trends that will drive the growth of AI in drug discovery for the next 5 years?
The need to reduce R&D costs is a major drive. Lead optimisation is the highest cost per launched drug due to the number of projects researched that never reach the market. Improving discovery efficiency through high quality candidates that are discovered effectively would dramatically improve these metrics. Exscientia’s deal with GSK is looking at this exact problem, designing candidates in a highly productive manner.
Also, the need to reduce healthcare costs – combination therapies (e.g in cancer) looking to become prohibitively expensive – AI approaches can be used to design drugs that could modulate multiple biological process (e.g blocking tumour signalling and survival mechanism, boosting immune response), in a costeffective manner. Exscientia is looking to tackle efficacy directly by design a breed of small molecules that we call bispecific small molecules. These are single small molecules with carefully designed dual pharmacology. Exscientia projects focus on I/O (with Evotec) , diabetes (with Sanofi) and psychiatric diseases (Dainippon Sumitomo Pharma).
What factors will play a critical role in the success of AI driven drug discovery projects?
Delivery on the promise.
Exscientia has already demonstrated the delivery of a clinic-ready candidate from the start of a project in a quarter of the time and a quarter of the cost co...
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