Category:
Advanced Intermediates
CAS NO:
2252-44-0
Standard:
USP,IP,
1-Bromo-3-(trifluoromethoxy)benzene undergoes Diels-Alder reaction with lithium diisopropylamide (LDA) in THF and furan, to yield the corresponding 1,4-dihydro-1,4-epoxy-5- or 6-(trifluoromethoxy)naphthalenes.
1-Bromo-3-(trifluoromethoxy)benzene (CAS: 405-26-9; Formula: C7H4BrF3O) is a key halogenated aromatic intermediate synthesized via electrophilic bromination of meta-trifluoromethoxybenzene. It serves as a critical building block in pharmaceutical and agrochemical synthesis.
Store under inert atmosphere at controlled temperatures below 25°C. Use appropriate PPE including respirators and chemical-resistant gloves due to potential respiratory irritation and environmental toxicity. Do not use in food or cosmetic applications.