Category:
Chiral Intermediates
CAS NO:
808118-40-3
Standard:
Ph. Int,
2-(4-HYDROXY-1-METHYL-7-PHENOXYISOQUINOLINE-3-CARBOXAMIDO)ACETIC ACID(Roxadustat)
Roxadustat is a hypoxia-inducible factor prolyl hydroxylase inhibitor. Its molecular formula is C20H18N2O4 and CAS No. is 1296775-27-9. The core synthesis involves coupling 2-(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxamido)acetic acid derivatives via amide bond formation.
Strictly contraindicated in severe hepatic impairment. Store under inert atmosphere at 2-8°C to prevent hydrolysis. Personal protective equipment is mandatory during handling due to potential irritancy.