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Overview
(2-Aminocarbonylphenyl)boronic acid is a specialized organic boron reagent used in palladium-catalyzed cross-coupling reactions. Its core synthesis involves the lithiation of 2-aminobenzamide followed by quenching with trialkyl borates. The compound features the molecular formula C7H8BN O2 and CAS number 159647-05-3.
Application
- Pharmaceuticals: Synthesis of heterocyclic scaffolds for kinase inhibitors.
- Agrichemicals: Production of novel herbicides via Suzuki-Miyaura coupling.
- Materials Science: Fabrication of functionalized liquid crystals and luminescent polymers.
Precautions
Maintain storage under inert atmosphere at low temperatures to prevent oxidation. Personnel must wear appropriate PPE including gloves and eye protection due to potential skin irritation and respiratory hazards during handling.