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Overview
3-Acetamidophenylboronic acid is a specialized organic intermediate primarily synthesized via the lithiation of acetanilide followed by reaction with trialkyl borates. It serves as a critical building block in medicinal chemistry for constructing complex heterocyclic scaffolds. The compound features the molecular formula C8H10BNO2 and carries CAS No. 5796-47-6.
Application
- Pharmaceutical Synthesis: Utilized in the preparation of kinase inhibitors and antiviral agents through Suzuki-Miyaura cross-coupling reactions.
- Material Science: Employed as a precursor for functionalized liquid crystals and fluorescent probes.
- Research: Applied in library synthesis for high-throughput screening of novel bioactive compounds.
Precautions
Store under inert atmosphere at temperatures below 25°C to prevent hydrolysis. Personnel must utilize appropriate PPE, including gloves and goggles, due to potential irritant properties. This substance is strictly for research use only and is not approved for direct clinical administration.