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Overview
3-Azido-7-hydroxy-2H-chromen-2-one is a specialized photoaffinity probe featuring a coumarin scaffold modified with an azide group for bioconjugation. Synthesized via nitration of 7-hydroxycoumarin derivatives, it serves as a critical intermediate in medicinal chemistry. Molecular formula: C10H5N3O4; CAS No.: 126894-85-1.
Application
- Pharmaceutical research for enzyme activity mapping
- Drug discovery targeting protein-ligand interactions
- Development of fluorescent imaging agents
Precautions
Store under inert atmosphere at -20°C to prevent azide decomposition. Avoid exposure to light and heat. Use only in controlled laboratory settings due to potential toxicity and explosive hazards associated with organic azides.