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Overview
3-[(Dimethylamino)carbonyl]phenylboronic acid (CAS 1248675-92-0, C10H14BNO3) is a specialized organoboron intermediate synthesized via directed lithiation of N,N-dimethylbenzamide followed by reaction with trimethyl borate. It serves as a critical scaffold for constructing complex heterocycles.
Application
- Pharmaceuticals: Key building block in Suzuki-Miyaura coupling for kinase inhibitors.
- Agrochemicals: Synthesis of novel fungicides and herbicides targeting specific enzymes.
- Material Science: Precursor for functionalized organic light-emitting diodes (OLEDs).
Precautions
Store under inert atmosphere at -20°C to prevent hydrolysis. Handle with nitrile gloves in a fume hood due to potential skin irritation and respiratory sensitization. Not approved for direct clinical use; strictly industrial grade only.