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Overview
3-(Trifluoromethyl)phenylboronic acid (CAS: 1758-24-9, C7H6BF3O2) is a key boron building block synthesized via halogen-metal exchange or lithiation of 3-trifluoromethylbromobenzene. It serves as a critical intermediate in cross-coupling reactions.
Application
- Pharmaceutical synthesis for kinase inhibitors and antiviral agents.
- Material science for developing OLED emitters and fluorescent probes.
- Agrochemical research for novel herbicide active ingredients.
Precautions
Store under inert atmosphere at 2-8°C to prevent oxidation. Avoid direct contact with skin; use appropriate PPE due to potential respiratory irritation and environmental toxicity.