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Overview
5-Bromo-pyrimidine-4-carboxylic acid methyl ester is a specialized heterocyclic intermediate primarily synthesized via bromination of pyrimidine carboxylates. It serves as a critical building block in pharmaceutical R&D for constructing complex nitrogen-containing scaffolds.
- Molecular Formula: C6H5BrN2O2
- CAS Number: 100983-78-2
Application
- Pharmaceutical Synthesis: Used as a precursor for developing kinase inhibitors and antiviral agents targeting nucleic acid replication.
- Agrochemicals: Incorporated into the production of novel fungicides and herbicides requiring pyrimidine cores.
- Material Science: Utilized in synthesizing luminescent organic compounds and metal-organic frameworks (MOFs).
Precautions
- Storage: Maintain in a cool, dry environment below 25°C under inert atmosphere to prevent hydrolysis.
- Safety: Handle with appropriate PPE; avoid inhalation or skin contact due to potential irritant properties.
- Regulatory: Not approved for direct clinical use; strictly for industrial research and manufacturing processes only.