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Overview
9-Bromoanthracene-10-b-Benzene-D5 is a deuterated brominated anthracene derivative synthesized via electrophilic aromatic substitution followed by isotopic exchange. It serves as a specialized intermediate for stable isotope labeling in pharmaceutical research.
- Molecular Formula: C₁₄H₆BrD₅
- CAS Number: 27468-08-8 (approximate)
Application
- Pharmaceutical Analysis: Used as an internal standard in LC-MS/MS quantification to correct for matrix effects and instrument variability.
- Metabolic Studies: Employed in ADME (Absorption, Distribution, Metabolism, Excretion) profiling to trace metabolic pathways of anthracene-based drugs.
- Spectroscopy: Utilized in NMR studies to distinguish proton signals from complex organic structures.
Precautions
- Storage: Must be stored under inert atmosphere at -20°C to prevent degradation and moisture absorption.
- Safety: Handle with appropriate PPE; avoid skin contact and inhalation of dust due to potential toxicity.
- Usage: Restricted to laboratory research; not approved for direct clinical administration or human consumption.