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Overview
Abiraterone acetate (CAS: 154229-19-7) is a potent inhibitor of CYP17A1, a key enzyme in androgen biosynthesis. Its molecular formula is C24H31NO3. The core industrial process involves the synthesis of steroidal derivatives via specific catalytic hydrogenation steps to ensure high purity for pharmaceutical API standards.
Application
- Oncology Manufacturing: Primary active ingredient in treatments for metastatic castration-resistant prostate cancer (mCRPC).
- Research Chemicals: Used in preclinical studies for androgen receptor pathway modulation.
- Formulation Development: Sourced by API manufacturers for combination therapies with prednisone.
Precautions
Strictly contraindicated in patients with severe hepatic impairment. Requires storage below 25°C in dry, light-resistant conditions. Handling mandates PPE due to potential endocrine disruption risks during manufacturing.