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Overview
ABT199 INT 2 is a critical synthetic intermediate for venetoclax, a selective BCL-2 inhibitor. The core process involves precise cyclization and coupling reactions to ensure high purity. Molecular formula: C24H25ClN6O3; CAS No.: 1207838-66-3.
Application
- Pharmaceutical Manufacturing: Essential API precursor for oncology drug production.
- R&D Laboratories: Used in clinical trial synthesis and pharmacological studies.
- Contract Manufacturing: Sourced by CDMOs for large-scale venetoclax formulation.
Precautions
Requires storage under inert atmosphere at 2-8°C. Strictly handle with PPE due to potential mutagenicity; avoid inhalation or skin contact during industrial processing.