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Overview
Adefovir dipivoxil is a prodrug of adefovir, utilized as an antiviral agent. Its molecular formula is C17H28N5O6P and CAS number is 179034-29-0. The core synthesis involves phosphorylation and esterification processes to enhance oral bioavailability.
Application
- Treatment of chronic hepatitis B virus (HBV) infections.
- Pharmaceutical manufacturing for anti-retroviral formulations.
- Research and development of nucleotide analog inhibitors.
Precautions
Contraindicated in patients with severe renal impairment without dose adjustment. Requires storage below 25°C in dry conditions. Strict safety protocols are mandatory during handling due to potential nephrotoxicity.