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Overview
AFATINIB is a second-generation irreversible ErbB family blocker used in oncology. The core synthesis involves complex heterocyclic coupling. Its molecular formula is C21H24ClFN4O3 and CAS number is 650798-08-8.
Application
- Targeted therapy for EGFR-mutated non-small cell lung cancer (NSCLC).
- Treatment of patients with acquired resistance to first-generation tyrosine kinase inhibitors.
- R&D of combination therapies in solid tumor clinical trials.
Precautions
Strictly contraindicated during pregnancy due to teratogenicity. Requires storage below 25°C in dry, light-resistant conditions. Handling demands PPE to prevent inhalation or skin contact with active pharmaceutical ingredients.