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Overview
Afatinib Dimaleate is a second-generation irreversible ErbB family blocker used in oncology. Synthesized via coupling afatinib with maleic acid, it features the molecular formula C25H27N7O6S and CAS No. 1084827-08-2.
Application
- Treatment of non-small cell lung cancer (NSCLC) with EGFR mutations.
- Targeted therapy for patients progressing on prior tyrosine kinase inhibitors.
- Pharmaceutical bulk manufacturing for oral tablet formulations.
Precautions
Contraindicated in severe hepatic impairment. Store below 25°C in dry conditions. Handle with PPE to avoid inhalation or skin contact due to potential toxicity.