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Overview
Alteplase is a recombinant tissue plasminogen activator (rt-PA) produced via genetic engineering for thrombolytic therapy. Its molecular formula is C1089H1675N297O334S10, and CAS No. is 9002-73-0.
Application
- Acute Myocardial Infarction: Reperfusion therapy to restore coronary blood flow.
- Ischemic Stroke: Intravenous administration within the therapeutic window to dissolve clots.
- Pulmonary Embolism: Treatment of massive PE with hemodynamic instability.
Precautions
Strictly contraindicated in active internal bleeding or recent intracranial surgery. Store lyophilized powder at 2°C to 8°C; reconstituted solution must be used immediately as it lacks preservatives.