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Overview
Alvimopan is a peripherally acting mu-opioid receptor antagonist (PAMORA) synthesized to reverse opioid-induced bowel dysfunction. Its molecular formula is C26H30N4O5 with CAS No. 179658-31-0.
Application
- Postoperative Ileus Management: Accelerates gastrointestinal recovery in patients undergoing bowel resection.
- Opioid Tolerance Mitigation: Counteracts constipation without interfering with central analgesic effects.
- Surgical Recovery Protocols: Integrated into Enhanced Recovery After Surgery (ERAS) pathways.
Precautions
Strictly limited to short-term hospital use (maximum 15 days). Contraindicated in patients with known or suspected mechanical gastrointestinal obstruction. Requires controlled storage at 20°C to 25°C away from moisture.