Category:
Active Pharmaceutical Ingredients
CAS NO:
54-62-6
Standard:
In-house Standards,
Aminopterin is a potent folic acid antagonist synthesized via p-aminobenzoic acid condensation. Its molecular formula is C19H20N8O5 (CAS: 59-06-4). This compound acts by inhibiting dihydrofolate reductase, disrupting nucleotide synthesis in rapidly dividing cells.
Strictly limited to laboratory research; not approved for clinical therapy due to severe toxicity. Requires storage at -20°C in a desiccated environment. Personnel must utilize PPE including nitrile gloves and fume hoods to prevent dermal absorption and inhalation risks.