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Overview
Amlodipine besylate is the benzenesulfonate salt of amlodipine, a long-acting dihydropyridine calcium channel blocker. Synthesized via condensation of ethyl 2-amino-5-chlorobenzylideneacetate with dimethyl acetylenedicarboxylate followed by besylation, its molecular formula is C20H25ClN2O5S (CAS: 88150-42-9).
Application
- Hypertension management in pharmaceutical formulations.
- Treatment of chronic stable angina and vasospastic angina.
- Cardiovascular protection in combination therapies.
Precautions
Contraindicated in severe hypotension or acute myocardial infarction. Store below 25°C in dry conditions to prevent hydrolysis. Handle with PPE to avoid skin contact and inhalation of dust.