-For symptom control of all forms of malaria
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Overview
Artesunate is a semi-synthetic derivative of artemisinin, widely recognized as a first-line treatment for severe malaria. Manufactured via chemical modification to enhance water solubility, its molecular formula is C₁₉H₂₈O₈ and CAS number is 84512-90-3.
Application
- Antimalarial Therapy: Intravenous or intramuscular administration for severe Plasmodium falciparum infections.
- Combination Therapies: Key component in Artemisinin-based Combination Therapies (ACTs) for uncomplicated cases.
- Research: Investigated for potential anti-cancer and immunomodulatory properties in clinical trials.
Precautions
Strictly contraindicated during the first trimester of pregnancy due to teratogenic risks. Requires storage in cool, dry conditions below 25°C away from direct sunlight. Medical supervision is mandatory to prevent delayed hemolysis post-treatment.