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Overview
AZA-Epothilone B is a synthetic analog of epothilones, featuring an azide group modification to enhance solubility and stability. Produced via semi-synthesis or fermentation with chemical tailoring, its molecular formula is C21H29N3O5 (CAS: 208469-74-5).
Application
- Pharmaceutical R&D: Serves as a critical intermediate for developing next-generation microtubule-stabilizing agents.
- Oncology Research: Utilized in preclinical studies to evaluate efficacy against taxane-resistant tumor models.
- Bioconjugation: Employed in antibody-drug conjugate (ADC) design due to the reactive azide moiety for click chemistry.
Precautions
Requires strict storage at -20°C under inert atmosphere to prevent degradation. Handle only in certified fume hoods using PPE; avoid inhalation or skin contact as it exhibits cytotoxicity. Not approved for direct clinical use outside controlled research protocols.