Category:
Respiratory System Drugs
CAS NO:
1421373-65-0
Standard:
In-house Standards,
AZD-9291
CAS NO: 1421373-65-0
MF: C28H33N7O2
MW: 499.61
Orally bioavailable mutant-selective EGFR inhibitor that has been tested in Phase III clinical trials for treatment of Non-Small Cell Lung Cancer
AZD-9291, known as Osimertinib, is a third-generation irreversible EGFR tyrosine kinase inhibitor. Its molecular formula is C30H33ClF3N4O4 with CAS number 752068-99-2. The core synthesis involves advanced organic coupling and fluorination processes.
Strictly store under controlled conditions at 2-8°C or room temperature per stability data. Handling requires PPE due to potential toxicity. Clinical use is restricted to patients with confirmed EGFR mutations; contraindications include severe hepatic impairment.