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*The following content is generated by AI and is for reference only.
Overview
Aztreonam USP Related Compound A, also known as Open-ring Aztreonam, is a critical degradation impurity of the monobactam antibiotic aztreonam. It forms via hydrolytic ring-opening of the beta-lactam core during synthesis or storage. Molecular Formula: C13H17N5O8S; CAS No.: 86092-46-6.
Application
- Quality Control: Serves as a reference standard for HPLC identification and quantification in pharmaceutical manufacturing.
- R&D Studies: Used to validate stability-indicating methods and understand degradation pathways.
- Regulatory Compliance: Essential for meeting ICH Q3A guidelines regarding drug substance impurities.
Precautions
- Storage: Maintain at -20°C in a dry, inert atmosphere to prevent further degradation.
- Safety: Handle with appropriate PPE; avoid inhalation or skin contact due to potential allergenicity.
- Usage: Strictly for research use only; not intended for clinical administration.