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Overview
Baloxavir marboxil is a prodrug of baloxavir acid, functioning as a cap-dependent endonuclease inhibitor for influenza A and B. The core synthesis involves esterification to enhance oral bioavailability. Molecular formula: C24H19F2N5O6; CAS No: 1708210-53-2.
Application
- Treatment of acute uncomplicated influenza in patients within 48 hours of symptom onset.
- Post-exposure prophylaxis for household contacts of confirmed influenza cases.
- Research applications for novel antiviral drug development targeting viral replication mechanisms.
Precautions
Contraindicated in patients with severe hepatic impairment. Store below 25°C in dry conditions away from light. Clinical use requires strict adherence to dosing guidelines to prevent resistance development.