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Overview
Barnidipine HCl is a dihydropyridine calcium channel blocker used in cardiovascular therapy. Synthesized via condensation of 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine with ethyl chloroacetate followed by reduction and salt formation. Molecular formula: C20H25N3O4·HCl, CAS No: 119837-85-7.
Application
- Pharmaceutical Manufacturing: API production for antihypertensive tablets.
- Research & Development: Preclinical studies on vascular smooth muscle relaxation.
- Quality Control: Reference standard for purity analysis in chromatography.
Precautions
Strictly controlled as prescription-only medicine; avoid use in severe hepatic impairment. Store under inert atmosphere at 2-8°C to prevent hydrolysis. Handle with PPE due to potential respiratory sensitization.