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Overview
Abemaciclib is a selective CDK4/6 inhibitor used in oncology therapy. Its molecular formula is C27H30N8O3 with CAS No. 1225336-39-3. The compound is synthesized via advanced heterocyclic coupling processes.
Application
- Advanced breast cancer treatment combined with endocrine therapy.
- Adjuvant therapy for high-risk early-stage HR+/HER2- breast cancer.
- Metastatic disease management in combination with fulvestrant.
Precautions
Contraindicated in severe hepatic impairment. Requires strict storage below 25°C in dry, dark conditions. Clinical use mandates monitoring for diarrhea, neutropenia, and liver enzyme elevation.