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Overview
Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in HIV treatment. Benzonitrile serves as a critical synthetic intermediate in its production via nucleophilic substitution. The molecular formula of Rilpivirine is C21H16N4, with CAS No. 500785-75-7.
Application
- HIV-1 therapy: First-line or second-line antiretroviral regimens.
- Pharmaceutical synthesis: Precursor for NNRTI active pharmaceutical ingredients.
- Organic chemistry: Solvent and reaction medium for heterocyclic synthesis.
Precautions
Strictly avoid use in patients with viral loads >100,000 copies/mL. Store benzonitrile precursors in cool, ventilated areas away from oxidizers; wear PPE to prevent inhalation or skin contact.