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Home Products Natural Extracts
Betulinic Acid Powder
Betulinic Acid Powder

Betulinic Acid Powder

Category:
Natural Extracts
Standard:
In-house Standards,
Price Range:
Get Quote
Main Sales Markets:
North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa
Send inquiry

Basic Info

Pharmacopoeia
In-house Standards
Grade
Food Grade
Is Manufacturer
YES

Product Description

What Is Betulinic Acid Powder?

 

Betulinic acid is a pentacyclic triterpenoid compound that exists widely in nature. It was first isolated from the bark of Rhamnaceae evergreen plants growing in East Africa, but the main source is extraction and purification from birch bark. In recent years, scientific research has found that BA is a very valuable natural product. BA plays an important role in the body's anti-oxidative damage and immune regulation process. It is a class of potential drug lead compounds and has great value for the development of new drugs.
Chemical name 3β-hydroxy-lup-20(29)-ene-28-oic acid, molecular formula C30H48O3, molecular weight 456.71, CAS number 472-15-1, boiling point 550.0±33.0 °C (Predicted), acidity coefficient (pKa) 4.61 ±0.70(Predicted), density 1.065±0.06 g/cm3(Predicted).

 

Test Report

 

ITEM

STANDARD

TEST RESULT

Betulinic Acid

98.0%

98.36%

Physical & Chemical

Appearance

White or off white fine powder

Complies

Odor

Characteristic

Complies

Bulk Density

0.1-0.2g/ml

Complies

Sieve analysis

100% pass 40 mesh

Complies

Extract Solvents

Ethanol

Complies

Loss on Drying

≤5.0%

3.48%

Heavy Metal

<10ppm

Complies

As

<1ppm

Complies

Pb

<3ppm

Complies

Cd

<1ppm

Complies

Hg

<0.1ppm

Complies

Residual Solvents

Ethanol ≤5000 ppm

Complies

BSE/TSE

Free

Complies

GMO status

Free

Complies

Kosher Status

Yes

Complies

Microbiological Test

Total plate count

≤1,000cfu/g

100cfu/g

Mold and Yeast

≤100cfu/g

45cfu/g

Coliform

Negative

Negative

E.Coli

Negative

Negative

Salmonella

Negative

Negative

Conclusion

Conform with specification, Allergen Free, BSE/TSE Free.

Storage

Store in cool and dry places. Keep away from strong light and heat

Packing

By 25kgs/Drum, inner by double plastic bag

Shelf Life

24 months under the above condition,and in it’s original package

What Are The Benefits?   

 

1. Anti-inflammatory effect
Most pentacyclic triterpenoids have anti-inflammatory activity. Both betulin and betulinic acid have mild anti-inflammatory properties at higher concentrations, and their anti-inflammatory properties may depend on the inhibition of protein kinase C without involving any neurogenic inflammatory mechanism. Studies have also indicated that its activity is the result of interaction with glucocorticoid receptors.
The anti-inflammatory effect of betulinic acid has been verified in model systems in vivo and in vitro. Betulinic acid can inhibit the production of PGE2 and reduce inflammation. Studies have shown that it has an inhibitory effect on mouse inflammation induced by carrageenan, phorbol, and bryostatin 1, but has no inhibitory effect on arachidonic acid-induced inflammation and neurogenic inflammation models.
2. Antibacterial effect
It has been found that betulinic acid has a certain antibacterial effect, and can inhibit a variety of bacteria including Escherichia coli, Bacillus subtilis, Staphylococcus aureus and Staphylococcus epidermidis. However, studies have proved that its antibacterial activity is weak, which may be due to the fact that it belongs to the lupine pentacyclic triterpenoids, and its structure is similar to that of the hopane pentacyclic triterpenoids, and there are biosynthetic hopane pentacyclic triterpenes on the bacterial membrane. related to the substance. Based on the research on the antibacterial ability of existing betulinic acid, it has little potential as an antibacterial drug.
3. Antiviral effect
Betulinic acid has relatively prominent antiviral activity, especially anti-HIV activity, and has effective effects on anti-hepatitis C virus, anti-herpes simplex virus, anti-echo virus, and anti-influenza virus.
4. Anti-hyperlipidemia effect
Studies have found that betulinic acid and its derivatives can play an anti-hyperlipidemic effect by regulating adipokines, reducing lipid production, and reducing triacylglycerol and total cholesterol levels.
5. Anti-diabetic effect
Betulinic acid has shown good efficacy in the treatment of diabetes, mainly by inhibiting α-amylase and α-glucosidase to reduce the hydrolysis of polysaccharides and promote glycogen synthesis.
6. Antioxidative stress activity
BA has a protective effect on normal cells and the body, which has a certain relationship with anti-oxidative stress. For example, betulinic acid has a protective effect on ischemia-reperfusion injury of the brain, kidney and heart. BA has a protective effect on ischemia-reperfusion brain injury in mice by resisting oxidative stress, resisting nitrification stress and increasing blood flow.
7. Other diseases
Now some studies have found that betulinic acid has a certain improvement effect on senile dementia. Its protective effect is mainly through attenuating neurobehavioral and cognitive dysfunction, reducing pro-inflammatory cytokines in the hippocampus, and reducing oxidative and nitrosative reactions.
At the same time, it is also reported in the literature that betulinic acid has certain anxiolytic effects, and some anxiolytic drugs have already applied betulinic acid components. This may be related to the high fat solubility of betulinic acid, which can penetrate the brain barrier

 

Application Direction

 

Betulinic acid powder has a very wide range of pharmacological effects, so it is widely used in the field of medicine and health products

Betulinic acid powder

Company Introduction And Certificates Obtained

 

Shaanxi Yuantai Biotechnology Co., Ltd. was established in 2014, mainly supplying herbal extracts, functional cosmetic raw materials, organic products, etc. We have our own factories, R&D and quality inspection teams, and have the conditions for development, production, and quality assurance. At present, we have obtained ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA and other certificates. Therefore, the quality of our products is guaranteed, and it is our original intention to bring high-quality products to customers.

product-750-450

Our Packaging​

product-750-540

Our Team

product-750-530