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Overview
Bevacizumab is a recombinant humanized monoclonal antibody targeting vascular endothelial growth factor A (VEGF-A). Synthesized via CHO cell fermentation, it inhibits angiogenesis. Molecular Formula: C6704H10582N1828O2112S46; CAS: 216974-75-3.
Application
- Oncology: Treatment of metastatic colorectal, non-small cell lung, glioblastoma, renal cell, and ovarian cancers.
- Ophthalmology: Management of neovascular age-related macular degeneration and diabetic macular edema.
Precautions
Contraindicated in patients with recent surgery or hemorrhage risks. Requires refrigerated storage at 2°C to 8°C. Strict aseptic handling is mandatory to prevent contamination.