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Overview
Bosutinib is a potent, oral dual SRC/ABL kinase inhibitor developed for oncology. It targets BCR-ABL1 mutations resistant to prior therapies. Molecular formula: C24H25N7O3S; CAS No.: 620829-63-8.
Application
- Hematologic Malignancies: Treatment of chronic myeloid leukemia (CML) in adults.
- Drug Resistance Management: Second-line therapy for imatinib-resistant or intolerant patients.
- Clinical Trials: Investigated for Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL).
Precautions
Monitor liver function and gastrointestinal toxicity strictly. Contraindicated in pregnancy; requires protective storage at controlled room temperature away from moisture.