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Overview
Brigatinib is a tyrosine kinase inhibitor primarily developed for oncology. Its molecular formula is C24H28ClFN6O and CAS number is 1257095-93-4.
Application
- Treatment of ALK-positive non-small cell lung cancer (NSCLC).
- Management of patients with resistance to prior crizotinib therapy.
- Targeted inhibition of ALK, ROS1, and EGFR mutations in clinical trials.
Precautions
Contraindicated in severe hepatic impairment; requires strict temperature control during storage. Clinical use mandates monitoring for pulmonary adverse events and hypertension.