COA available,high purity with single impurities<0.1%; >100kg/batch; comprehensive support for registration and submission; Manufacturer.
*The following content is generated by AI and is for reference only.
Overview
C20-γ-Glu(AEEA-AEEA-OSu)-OH is a specialized PEGylated crosslinker featuring a glutamic acid backbone and an active NHS ester. This bifunctional reagent facilitates stable amide bond formation with primary amines. Molecular formula: C41H67N5O12; CAS No.: 1899886-66-4.
Application
- ADC Development: Conjugation of cytotoxic payloads to antibody lysine residues for targeted cancer therapy.
- Bioconjugation: Labeling proteins, peptides, or enzymes for diagnostic assays and research tools.
- Drug Delivery: Construction of polymer-drug conjugates to enhance pharmacokinetic profiles.
Precautions
- Storage: Maintain at -20°C under desiccated conditions to prevent hydrolysis.
- Safety: Handle in a fume hood; wear appropriate PPE as the NHS ester may cause sensitization.
- Limitations: Not approved for direct clinical administration; strictly for R&D use only.