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Overview
CEDIRANIB is a potent, oral small-molecule inhibitor of vascular endothelial growth factor receptors (VEGFRs), primarily developed for oncology research. Its core synthesis involves complex heterocyclic coupling reactions. The chemical formula is C26H29ClN4O2 with CAS number 710588-42-4.
Application
- Oncology Research: Investigating anti-angiogenic mechanisms in solid tumor models.
- Drug Discovery: Screening for VEGFR2 inhibition activity in preclinical assays.
- Biomarker Studies: Evaluating tumor vasculature reduction under hypoxic conditions.
Precautions
Strictly for laboratory use only; not approved for human clinical administration. Store powder at -20°C under inert atmosphere to prevent hydrolysis. Handle with appropriate PPE due to potential cytotoxicity and reproductive hazards.