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Overview
Ceftizoxime Alapivoxil is a prodrug of the third-generation cephalosporin antibiotic Ceftizoxime, designed to enhance oral bioavailability. It utilizes an esterification process to improve lipophilicity for systemic absorption. The compound typically corresponds to molecular formula C20H21N9O8S3 and CAS No. 104357-68-8, though specific salt forms may vary by manufacturer.
Application
- Pharmaceutical Manufacturing: Bulk synthesis for respiratory tract infections and urinary tract infections.
- Antibiotic Formulation: Active ingredient in delayed-release tablet preparations targeting Gram-negative bacteria.
- Research & Development: Used in clinical trials evaluating prodrug stability and pharmacokinetic profiles.
Precautions
Strictly contraindicated for patients with severe cephalosporin hypersensitivity. Store in cool, dry environments below 25°C away from direct light. Personnel must utilize PPE including nitrile gloves and respirators during handling to prevent dermal exposure or inhalation of dust particles.