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Overview
Ceritinib is a highly selective ALK inhibitor used in oncology. It features the molecular formula C24H26FN5O3 and CAS number 790898-11-8. Production involves complex organic synthesis with high-purity crystallization.
Application
- Treatment of ALK-positive metastatic non-small cell lung cancer (NSCLC).
- Second-line therapy for patients resistant to prior crizotinib treatment.
- R&D applications in kinase inhibitor screening assays.
Precautions
Contraindicated in severe hepatic impairment. Requires storage below 25°C in dry conditions. Monitor liver enzymes and QT interval during clinical administration.