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Overview
Cetilistat is a potent, reversible pancreatic lipase inhibitor developed for obesity management. Its core process involves asymmetric synthesis to achieve high optical purity. The compound features the molecular formula C29H41NO4 and CAS number 78563-50-1.
Application
- Pharmaceutical Manufacturing: Active ingredient in anti-obesity formulations targeting lipid malabsorption.
- Clinical Research: Used in Phase III trials to evaluate weight loss efficacy alongside lifestyle interventions.
- Nutraceuticals: Investigated for inclusion in dietary supplements managing metabolic syndrome.
Precautions
Strictly contraindicated for patients with chronic malabsorption syndromes or cholestasis. Storage requires sealed containers at controlled room temperature (20-25°C) away from moisture. Clinical use mandates monitoring of fat-soluble vitamin levels.