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Overview
Cetuximab is a chimeric monoclonal antibody targeting the EGFR receptor. It is produced via recombinant DNA technology in mammalian cell lines. Formula: C6528H10104N1728O2098S44. CAS: 205923-16-4.
Application
- Oncology Manufacturing: Treatment of metastatic colorectal cancer and head and neck squamous cell carcinoma.
- Diagnostics: Companion diagnostic testing for KRAS/NRAS mutations prior to therapy initiation.
- R&D Supply: Bulk API sourcing for clinical trial formulations and stability studies.
Precautions
Requires strict adherence to hypersensitivity reaction protocols during infusion. Storage must be maintained at 2°C to 8°C without freezing. Contraindicated in patients with known severe hypersensitivity to murine proteins or cetuximab itself.