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Overview
Clopidogrel bisulphate is a potent antiplatelet agent available as crystalline polymorphs I and II. Synthesized via condensation of 2-chlorobenzyl chloride with thienopyridine derivatives, it exists in distinct solid-state forms. The molecular formula is C16H16ClNO2S·H2SO4, with CAS No. 91276-48-7.
Application
- Pharmaceutical Manufacturing: Primary API for preventing thrombotic events in patients with acute coronary syndrome.
- Cardiovascular Therapeutics: Used post-percutaneous coronary intervention (PCI) to inhibit platelet aggregation.
- Research & Development: Standard reference material for stability studies on polymorphic transitions.
Precautions
Contraindicated in patients with active bleeding or severe hepatic impairment. Requires storage in cool, dry environments below 25°C to prevent hygroscopic degradation. Strict occupational exposure limits apply during powder handling to avoid inhalation risks.