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Overview
Colesevelam Hydrochloride is a bile acid sequestrant synthesized via cross-linking cholestyramine derivatives. It functions as a polymer resin to bind bile acids in the intestine, preventing reabsorption. Molecular formula: C45H69Cl2N2O18; CAS No.: 147026-17-5.
Application
- Dyslipidemia management for lowering LDL cholesterol.
- Type 2 diabetes mellitus adjunct therapy for glycemic control.
- Bile acid diarrhea treatment in patients with ileal dysfunction.
Precautions
Contraindicated in complete biliary obstruction or bowel obstruction. Store below 25°C in dry conditions. Avoid concurrent administration with other oral medications within 4 hours to prevent absorption interference.