Products

Suppliers

News

All Categories

Products or Suppliers

Content Hub

Product Zone

Sponsorship & Membership

CPHI & PMEC China

Active Pharmaceutical Ingredients Intermediates&Fine Chemicals Bio Products Natural Extracts Finished Dosage Pharmaceutical Excipients Pharmaceutical Outsourcing, Customised Services, and Consulting Medical Aesthetic Skincare Food Ingredients API Equipment Preparation Equipment Pharmaceutical Packaging Machinery TCM Machinery Pharmaceutical water equipment Clean Technology Refrigeration Equipment Parts and Components Informatization Products Laboratory Packaging Materials Measuring Instrument Environmental Protection Equipment Logistics Other Consumables Dietary Supplements‌‌

Correctives Colorant Filtration separation Intelligent Logistics Cold chain Technical &Materials Logistics Equipment &Materials Storage Equipment &Materials Logistic Services Third-party logistics Dangerous Goods Logistics Level instrument Pressure gauge Thermometers Flow meter Gas analysis instrument Liquid analysis instrument Fermenter Equipment Other Measuring Instrument Other Logistics Medical Aesthetic Consumables Sera and Vaccines Soft tube/Hard tube Pharmaceutical Intermediates Anti-tumor Preparations Pharmaceutical Manufacturing Outsourcing Chemical and Biochemical Reactors Mixing Equipment CIP System(Clean in place) Herbal medicine Concentration Equipment Purification Equipment Low Temperature Refrigeration Seals Laboratory General Equipment Functional Food Raw Materials Inner packaging equipment Polluted Water / Wastewater Treatment Equipment Injection Raw Materials and Ingredients IVD (In Vitro Diagnostics) Consumables Suspending Agents / Thickening Agents Concentrator Equipment MES System APIs for Anti-Infective Drugs Biochemical APIs Botanical products Pharma Packaging Materials Diluents (Fillers) Intermediates for Agrochemicals Reagent Cardiovascular, Cerebrovascular, and Circulatory System Formulations Pharmaceutical R&D Outsourcing Drying Equipment TCM Pulverizer Water Purification Equipment Purification Test Instrument Air Conditioner ‌Sanitary Fittings Analytical Instrument Other Dipstick Consumables Nutraceutical Ingredients Granules Machinery Outer packaging Waste Gas Treatment Equipment Active Ingredients Binders Solubilizers Drug delivery systems Sensors APIs for Nervous System Drugs Animal-derived products Endocrine and Metabolic Preparations Disintegrants service Crystalling Equipment Pill Making Equipment Other Water Treatment Equipment Clean Clothes/Clean Cap/Clean Shoes Cold Storage Pumps Food & Beverage Raw Materials Life Science Instrument Tablet equipment Other pharmaceutical packaging equipment Solid and Hazardous Waste Treatment Equipment Innovative Materials Controllers & Drivers Speciality Intermediates Microbial products Humectants APIs for Digestive System Drugs APIs for Cardiovascular System Drugs Antibacterial and Antiviral Formulations Lubricants Extraction Plant Slice Machine Clean Bench ‌Refrigeration Auxiliaries Valves Biologics TCM Raw Materials Food Additive Reagents and Consumables Capsule equipment Pharmaceutical water equipment Testing & Monitoring Instruments and Equipment Other Medical Aesthetics & Skincare Veterinary Pharmaceutical Intermediates Automation Software APIs for Respiratory System Drugs Bio Technology Service Antipyretic and Analgesic Preparations Glidants / Anti-caking Agents Heat Exchanger Herbal medicine Drying Equipment Air Shower Room Compressor Cylinders Fine Chemicals Crushing equipment Ultrapure Water System Other Automation & Informatization Products OEM/ODM Measuring Instruments Energy-saving and Low-carbon Equipment Other Intermediates Antiparasitic Preparations Coating Agents Storage Tanks, Containers Herbal medicine Extraction Equipment Air Purification Other Refrigeration Equipment Drive Equipment‌ Liquid preparation equipment Solution Preparation System Other Environmental Protection Equipment APIs for Hormones and Regulatory Drugs Other Natural Products Physical Testing APIs for Antiparasitic Drugs Anti-Allergic Formulations Plasticizer Evaporating Equipment TCM Cooking Equipments Cleanroom Reducers Laboratory Engineering Biopharmaceutical Equipment Membrane Module‌ APIs for Antipyretic and Analgesic Drugs Anti-Tuberculosis and Anti-Leprosy Formulations Surfactant Distillation Equipment Drop Pill Equipment Purifying Engineering VFD (Variable Frequency Drive) Other preparation equipment Distilled water machine Laboratory Solutions Vitamin Digestive System Preparations Centrifuge Screening Machine Honey Pill Machine Flooring Materials Bearing Emulsifiers Ion-exchange equipment Online Process Control Respiratory System Preparations Sterilizing Equipment TCM Deposition Equipment Spare Part‌ Other Cleaning System Stainless Steel Nervous System Preparations Filter press equipment Herbal medicine Fermentation Equipment Plastic ‌Containment System Special Active Ingredients Ointment Bases Homogenizer Equipment Other TCM Machinery Others Parts and Components APIs for Veterinary Drugs and Feed Additives Anaesthetic and Adjuvant Formulations Air Filter Suppository Bases Other Active Pharmaceutical Ingredients Blood System Formulations Cleanroom Consumables‌ Glass lining equipment Film-forming Agents Urinary and Reproductive System Formulations Other API Machinery and Equipment Filter Paper Release Modifiers Immunomodulatory Formulations Filter Paper Board smotic Pressure Regulators / Tonicity Adjusting Agents Water, Electrolyte, and Acid-Base Balance Regulating Formulations Ph Control Agents Nozzle, Tank Cleaning Machine Vitamin, Mineral, and Amino Acid Formulations Antioxidants / Antioxidant Synergists Fluid Equipment Enzyme and Other Biochemical Formulations Antimicrobial Preservatives (Preservatives) Tonic and Nutritional Formulations Complexing Agents (Chelating Agents / Inclusion Compounds) Hormonal Formulations Dermatological Preparations Other Preparations Co-solvents ENT Preparations Penetration Enhancers (Transdermal) Freeze-drying Protective Agents Refrigerants / Cryogens Capsule Fragrances Adsorbents Pressure-sensitive Adhesives (PSA) Stiffening Agents Carriers for Dry Powder Inhalers (DPI Carriers) Other Excipients

Pipes and Pipe Fittings Vacuum Equipment Air Compressor Compressor Other Fluid Equipment Prefillable Syringes Filters Filter Presstem Filtration System Filter Bag Filter Mesh Filter Cloth Filter Membrane Other Filtration Equipment Sanitary Pressure Vessel‌ Hyaluronic Acid Collagen Botulinum Toxin Peptide Other Injection Raw Materials and Ingredients Ceramide Ectoin Niacinamide Asiaticoside Ergothioneine Chitosan Other Active Ingredients Chiral Intermediates Advanced Intermediates Microfiltration Ultrafiltration Auxiliary Equipment Separation equipment Metered Dose Inhalers Dry Powder Inhalers Penicillin Hormones Central Nervous System Drugs Reagents for Biopharmaceuticals Drug Target Discovery and Validation Plant Extracts Animal Extracts Synthesis/Screening Process Development/Optimisation/Scale-Up Production Drug Registration and Submission Services Ointment Filling-sealing Machine、Vacuum Mixer Eye Drug Machinery Soft Gelatin Capsule Machinery Tablet Press Pneumatic Cracker Granulator Labelers, Label Printers Bag Packaging Machine Thermostatic / Heating / Drying Equipment Chromatography Particle Size / Particle / Powder Analysis Instruments Tabletop Glass bottles & Vials Fermentation Products Prophylactic Biological Products Mixing Tank/Blender Bioreactor Intravenous Infusion Set Assembly Equipment(Pen Assembly Equipment) PCR Recombinant Collagen Alkaloids Veterinary API Regulated Fine Chemicals Peptides Balances / Weighing Scales Online Gas Chromatography Cephalosporins Anesthetics Immunology Reagents Drug Development Technologies Pharmaceutical Chemistry Formulation Design Regulatory and Compliance Consulting Syrup Machinery Injection Medicine Machinery Hard Capsule Filling Machine Coating Machine Medicine Material Grinding Machine Lettering machine Box Packaging Machine Mass Spectrometry Laboratory Bench Aluminum Foil Rheometers / Viscometers ‌Chemical Reagents Cleaning & Disinfection Equipment Granulator Emulsifier Biological Fermentation System Injection Molding Equipment Exosome Phospholipids Prostaglandins Veterinary Biologics Chemical Reagents Therapeutic Biological Products Biochemical Reagents Antibodies Natural Pigments Animal Lipids Enzyme Preparations Flowmeters Online Particle Size Analyzer Tetracycline Amino Acids and Derivatives Process Optimization and Testing Nucleic Acids and Derivatives Pre-Clinical Research Chemical/Biological API Manufacturing Powder Filling Machine Oral Liquid Machinery Low Temperature Pulverizer Strapping machine Paper Film Packaging Machine Thermal Analyzers Spectrometers Other Measurement and Metrology Instruments Storage Cabinets Plastic Bottles Other Industrial Process Control and Online Analytical Instruments Certification Feed Additives Diagnostic Biological Products Pulverizer Coating Machine Capsule Filling Machine Other Mixing Equipment Cell Engineering Equipment Pre-filled Syringe Production Equipment Purification Equipment Electrophoresis/Gel Imaging/UV Detection Regenerative Materials Other Fine Chemicals Cell Biology Reagents Biological Consumables Feed Additives Soft Mist Inhaler Plant Polysaccharides Animal Proteins Microbial Polysaccharides Aminoglycoside Enzymes Molecular Biology Reagents Clinical Trials Intermediate Synthesis and Production Market and Business Strategy Consulting Suppository Drug Machinery Powder Injection Machinery Pharmaceutical Milling Machinery Printing Device Blister Packaging Machine Environmental Test Chambers Moisture Analyzer Air Discharge Equipment Rubber Stopper Tablet Press Other Tablet Equipment Capsule Production Line Isolator Synthesis/Reaction Equipment Microbial Detection Instrument Composite Biomaterials Animal Breeding Auxiliary Products Packaging Testing Equipment Laboratory Glassware and General Consumables Preclinical Research Services Nebulizer Essential Oils Animal Polysaccharides Bioactive Functional Ingredients Macrolides Microbial / Fermentation Reagents Proteins Other Technology Services Biotechnology Services Formulation Development and Manufacturing Other Services Medicine Film Drug Machinery Infusion Medicine Machinery（中文站有输液剂机械的三级分类） Pharmaceutical Machine Milling Instruction Booklet Folding Machine Fan Chromatography Consumables and Accessories Other Physical Properties Testing Instruments Gasket Sample Preparation / Digestion Equipment X-ray Structure Analysis Safety Cabinet Counting Machine (Tablet) Other Capsule Filling Equipment Disposable Biotechnology Equipment Vacuum Packaging Machine Laboratory Low-temperature Storage Other Innovative Materials Other Veterinary Conveying equipment Natural Spices Bile Acids and Active Ingredients Sulfonamides Other Specialized Reagents Computational Chemistry and AI-Assisted Drug Design Clinical Trial Drug Manufacturing Aerosol Drug Machinery Super Micro Mill Bottle Conveyer Bundling Packaging Machine Mixing/Dispersion Equipment Other Laboratory Complete & Ancillary Equipment Trays Other Laboratory Consumable Other Preparation Machinery for Solid Medcine ‌Centrifugal Separation System Automatic Packaging Machine Other Analytical Instrument Chip System/Accessories Cytokines Counting Machine Cartridge Vial Medicinal Herbs Bee Products Chloramphenicols Testing Other Pharmaceutical Manufacturing Outsourcing Medicine Filling Machine Disk Type Bottle Straightening Machine Lidding Materials Other Crushing Equipment Ultrafiltration/Microfiltration System Horizontal Pillow Packaging Machine Cartoning Machine Auto-injector Transfection/Cell Fusion Track & Trace Gas Generators / Gas Handling Equipment Blood Products TCM Ingredients & Slices Animal Medicinal Materials Lincomycin Microbial Products Bottle Washer Vial Sealing Machine Liquid Handling Equipment Hoses and Fittings Other Biopharmaceutical Equipment Vertical Packaging Machine Casing Machine Microplate Reader/Enzyme Labeling Instrument Analysis and Validation Serialization System Pen Injector Other Anti-Infective Drug Other Pharmaceutical R&D Outsourcing Conveyer For Medicine Material Spray Pump Other Injectable Equipment Aluminum Foil Packaging Machine Coding Machine Cell Analysis Automated Assembly Other Laboratory General Equipment Packaging Bag Valve Freeze Dryer Granule packaging machine Other Drug Delivery Device Accessories Biological Microscope/In Vivo Imaging Other Antibiotics Cap Screwing Machine Nasal Drug Delivery Devices / Nasal Spray Pumps Printing Services‌ Liquid Packaging Machine Laboratory Automation Screw Capping Machine Lamp Inspection Machine Ophthalmic Drug Delivery Devices / Eye Drop Delivery Systems Labelling Powder Packaging Machine Synthesizer Heat Shrink Packaging Machine Metal Detector Insulin Pens / Blood Glucose Management Devices Security Taggants & Markings Filter Cartridge‌ Tablet Packaging Machine Animal Experiment Instrument Injection & blow molding machines Batching system Self-Injection Systems / Safety Protection Devices Incubator Equipment Printed Drugs Packaging Box filling & sealing machine Palletizing equipment CIP cleaning system Topical / Gynecological / Intimate Drug Delivery Devices Desiccants Other Life Science Instrument Bottle Filling Line Contaners Lifting Charging Machine Others Inhalant Packaging BFS Bottlepack Machine Weighting Equipment Blister Packaging Machine Pharmaceutical Paper Other Pharmaceutical Outer Packaging Equipment Packaging bag valve Container Sealing Machine Glass Tube Multi-functional Bottle Packaging Machine Medical Aesthetic Freeze-Dried Powder Vials Sachets Cartoner Packing line Primary Packaging Other Pharmaceutical Inner Packaging Equipment Aluminum Caps & Aluminum-Plastic Combination Caps Sterile Bags / Breathing Bags / Sterilization Bags Medical Device Packaging / Bioconsumables Packaging Dispensing Bottles Blister Packaging Pharmaceutical Plastic Films / Composite Film Bags Accessories Ampuls Other Packaging Materials

Products Suppliers Match & Meet

Industry Insights E-Learn Series Pharma Sources Insight

E-trade Season PharmaExpress

Service & Membership Contact Us

CPHI China PMEC China CPHI & PMEC Shenzhen

Home Products Veterinary API

Colsitin sulphate

Category:

Veterinary API

CAS NO:

1264-72-8

Standard:

EP,

Price Range:

Get Quote

Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

Send inquiry

Arshine Group Co.,Ltd.

Years

Show Room

Favorites

Basic Info

CAS Number

1264-72-8

Pharmacopoeia

Grade

Veterinary Grade

Is Manufacturer

YES

Samples Provided

Product Description

Sulfate colistin, also known as colistin, polymyxin E, antibiotics, etc., is a white or nearly white powder, odorless, bitter and hygroscopic, easily soluble in water, slightly soluble in methanol and ethanol, almost insoluble in acetone, ether and other chemicals, and slightly soluble in free alkali in water. Stable within the pH range of 3-7.5. Sulfate colistin is produced by polymyxin and has a strong antibacterial effect on Gram negative bacteria. It is used to treat intestinal diseases caused by Gram negative bacteria, as a feed additive, and has a significant growth promoting effect. It works well when combined with sulfamethoxazole.

Pharmacodynamics
Sulfate colistin belongs to the narrow spectrum fungicide. It has a strong antibacterial effect on Gram negative bacteria such as Escherichia coli, Salmonella, Pasteurella, Shigella, Brucella, Vibrio, and Pseudomonas aeruginosa. Among them, it has a strong bactericidal effect on Pseudomonas aeruginosa and Vibrio. The bactericidal mechanism is to damage the bacterial cell membrane, increase its permeability, and cause leakage of amino acids, purines, pyrimidines, K+, and other substances in the bacterial body. It can also affect the nuclear and ribosomal functions, leading to bacterial death. Bacteria are not easily resistant to this product and have complete cross resistance to polymyxin B. However, there is no cross resistance to other antibiotics. All Gram positive bacteria, as well as Proteus, Brucella, and Serratia, are resistant to this product. Sulfate colistin is mainly used to treat intestinal infections caused by Gram negative bacteria, and for topical treatment of Pseudomonas aeruginosa infections caused by burns and trauma. As a feed drug additive, it has a growth promoting effect.

Pharmacokinetics
This product is rarely absorbed when taken orally, and after absorption, the distribution of the drug in the body is poor, with a short duration. After 8 hours of oral administration, except for bile, there were only trace amounts in other tissues, and after 16 hours, there was no residue in all tissues. After injection, it is widely distributed in the body and reaches its peak in the main tissues within 0.5-1 hours. However, it is not easy to penetrate into the chest cavity, joint cavity, and infection site, and it is also difficult to enter the cerebrospinal fluid. After 6 hours, it cannot be detected except for blood, trachea, salivary glands, kidneys, and urine. After 24 hours, it cannot be detected except for trachea, kidneys, and urine. The protein binding rate of drugs is relatively low. Mainly excreted through the kidneys, it is prone to accumulate in the body when renal function is incomplete.

Antiendotoxin
Endotoxins are a type of toxin synthesized, produced, and released by bacteria, composed of O-specific side chains, core polysaccharides, and lipid A. All antibiotics have the problem of causing bacterial endotoxin release, while colistin sulfate has the lowest bacterial endotoxin release. More importantly, colistin sulfate can neutralize endotoxins by binding positively charged - NH2 to the negatively charged phosphate root on endotoxin lipid A produced by bacteria; Therefore, sulfated colistin can eliminate bacterial endotoxins, inhibit the release and activity of bacterial endotoxins, and is a good anti endotoxin drug. According to research reports by L ü Genfa et al. (2004), once endotoxins bind to receptors on the cell surface and mediate cell activation, colistin sulfate will lose its anti endotoxin effect. Therefore, supporting the direct neutralization effect of colistin sulfate on endotoxins is the main way to antagonize endotoxins.

pharmacological activity
Sulfate colistin has antibacterial activity mainly due to its molecular structure consisting of three key active groups: fatty acids, positively charged amino acids, and cyclic peptides. Missing or changing any of the above structures will significantly reduce their bactericidal activity. Sulfate colistin has a bactericidal effect, mainly as a positively charged free amino group that can bind to negatively charged phosphate ions in the phospholipids of bacterial cells, reducing the surface tension of the bacterial cytoplasmic membrane and disrupting its integrity. This increases the permeability of the cell membrane, causing the main components of the cell, especially purines and pyrimidines, to flow out of the cytoplasm, thereby inhibiting bacterial growth or leading to bacterial death. Due to the high content of phospholipids in the cell membrane of Gram negative bacteria, while the phospholipid content in the cell membrane of Gram positive bacteria is extremely low, the antibacterial effect of colistin sulfate is mainly the strongest against Gram negative bacteria. In view of this, the antibacterial spectrum of sulfated colistin is limited to Gram negative bacteria such as Escherichia coli, Salmonella, Pasteurella, Pseudomonas aeruginosa, and Hemophilus. Moreover, these bacteria typically exhibit widespread resistance to commonly used aminoglycosides, penicillin, cephalosporins, fluoroquinolones, and other antibiotics; Moreover, many bacteria have multiple drug resistance. However, sulfated colistin is not easy to develop resistance, and to date, no resistance has been found against the spread of sulfated colistin resistant plasmids. So, the diffusion and spread of resistance to sulfated colistin is extremely slow, and currently, the vast majority of Gram negative bacteria are quite sensitive to sulfated colistin.

The characteristics of sulfated colistin
(1) Has extremely strong resistance to Gram negative bacteria. Especially, it has a specific developmental inhibitory effect on Escherichia coli, Salmonella, and Pseudomonas aeruginosa.
(2) It has a bactericidal effect. By hindering the selective permeability function of cell membranes, bacteria die
(3) There is almost no issue of drug resistance. No resistance to R factor was found.
(4) Synergistic effect with anti Gram positive bacteria drugs. When used in combination with zinc bacteriocins, aflatoxins, sulfonamides, semi synthetic penicillin, gentamicin, etc., the effect is even better.
(5) No residue. When administered orally, it is almost not absorbed by the intestine, but during intramuscular injection, blood collection and absorption are good, so there is no need to worry about residues in animal products.
(6) Promote the growth of livestock and poultry, and prevent and control infectious enteritis in livestock and poultry.

purpose
It belongs to the class of antibiotics and is used to treat intestinal diseases caused by Gram negative bacteria. It has a certain growth promoting effect and is mainly used for sensitive bacterial infections, such as sepsis, acute enteritis, urinary tract infections, etc. This product is produced by polymyxin bacteria and has a strong antibacterial effect on Gram negative bacteria. It is used to treat intestinal diseases caused by Gram negative bacteria. Sulfate colistin is used to penetrate the cell membrane of bacteria and study the anticoagulation effect of mannose, as well as the antibiotic resistance of certain organisms, such as Baumann. It has also been used to study the hepatotoxicity in rat kidneys, MIC values against Pseudomonas aeruginosa, time killing kinetics, and post antibiotic effects (PAE)