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Overview
Dabigatran etexilate is a prodrug of the direct thrombin inhibitor dabigatran. It is synthesized via esterification to improve oral bioavailability. Molecular Formula: C22H28N10O5. CAS No.: 294781-40-3.
Application
- Pharmaceutical Manufacturing: Active Pharmaceutical Ingredient (API) for anticoagulant tablets.
- Cardiovascular Therapy: Prevention of stroke and systemic embolism in non-valvular atrial fibrillation.
- Vascular Surgery: Prophylaxis of venous thromboembolism following hip or knee replacement surgery.
Precautions
Contraindicated in patients with severe renal impairment or active bleeding. Store at controlled room temperature below 25°C in dry, light-resistant containers. Handle with PPE to avoid inhalation of dust particles.