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Overview
Dabrafenib Mesylate is a selective BRAF V600E inhibitor used in oncology. Synthesized via controlled salt formation, its molecular formula is C21H24N8O5S and CAS No. 1279688-58-6.
Application
- Oncology: Treatment of unresectable or metastatic melanoma with BRAF V600 mutations.
- Combination Therapy: Paired with MEK inhibitors for non-small cell lung cancer (NSCLC).
- Research: Targeted validation in kinase signaling pathway studies.
Precautions
Contraindicated in patients with wild-type BRAF tumors. Store under controlled room temperature away from moisture. Handle with PPE to prevent dermal exposure during manufacturing.