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Overview
Daptomycin is a cyclic lipopeptide antibiotic produced via fermentation. It targets Gram-positive bacteria by disrupting cell membrane potential. Its molecular formula is C66H98N12O18 and CAS number is 107245-79-6.
Application
- Treatment of complicated skin and soft tissue infections.
- Management of bacteremia and right-sided infective endocarditis.
- Alternative therapy for methicillin-resistant Staphylococcus aureus (MRSA).
Precautions
Strictly monitor creatine phosphokinase levels to prevent myopathy. Avoid concomitant use with HMG-CoA reductase inhibitors. Store lyophilized powder at controlled room temperature below 25°C in a dry environment.