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Overview
Darunavir Ethanolate is a stable crystalline salt form of the HIV protease inhibitor Darunavir, synthesized via ethanol crystallization to enhance solubility and bioavailability. The molecular formula is C27H39N3O7S·C2H5OH, with CAS No. 160584-72-7.
Application
- Pharmaceutical manufacturing for antiretroviral therapy (ART) formulations.
- Production of fixed-dose combination tablets targeting resistant HIV strains.
- API supply chain for generic drug manufacturers in emerging markets.
Precautions
Strictly indicated only as part of combination therapy; contraindicated for monotherapy due to resistance risks. Store under controlled conditions at 2°C–8°C in moisture-proof containers to prevent hydrolysis or solvent loss.