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Overview
Daunorubicin Citrate is a stabilized anthracycline derivative synthesized via fermentation and chemical conjugation. It serves as the citrate salt form of the potent antitumor antibiotic daunorubicin, enhancing solubility for intravenous administration. The molecular formula is C27H30ClNO11·C6H8O7, with CAS No. 5945-48-2.
Application
- Oncology: Primary treatment for acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).
- Pharmaceutical Manufacturing: Used as an active pharmaceutical ingredient (API) in sterile injectable formulations.
- Research & Development: Employed in cytotoxicity assays to study cell proliferation mechanisms.
Precautions
Strictly contraindicated for intrathecal use due to fatal neurotoxicity. Requires handling under negative pressure fume hoods with full PPE to prevent exposure. Store at controlled room temperature (20-25°C) in dry, light-resistant containers away from moisture.