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Overview
Denosumab is a fully human monoclonal antibody produced via recombinant DNA technology. It targets RANKL to inhibit osteoclast formation and function. Molecular Formula: C65H102N18O41S4 (variable due to glycosylation). CAS No.: 936676-45-2.
Application
- Oncology: Management of bone metastases in solid tumors.
- Rheumatology: Treatment of postmenopausal osteoporosis.
- Growth Hormone Deficiency: Prevention of skeletal-related events.
Precautions
Strictly monitor for hypocalcemia and osteonecrosis of the jaw. Requires refrigerated storage at 2°C to 8°C. Avoid shaking to prevent protein denaturation during transport.