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Overview
Derquantel is a novel tetrahydropyrimidine anthelmintic developed for veterinary use. It functions as a potent antagonist of nicotinic acetylcholine receptors (nAChRs) in nematodes, disrupting neuromuscular transmission to induce paralysis and expulsion of parasites. The compound is characterized by the molecular formula C14H20N2O2 and carries the CAS number 187995-68-2.
Application
- Ruminant Health: Control of gastrointestinal nematodes in sheep and cattle, specifically targeting resistant strains.
- Combination Therapy: Frequently formulated with abamectin to broaden the spectrum against internal parasites.
- Livestock Management: Used in rotational grazing programs to mitigate resistance development in worm populations.
Precautions
Strictly for veterinary use only; not approved for food-producing animals prior to withdrawal periods. Avoid contact with eyes and skin; wear appropriate PPE during handling. Store in a cool, dry place away from direct sunlight and moisture to maintain chemical stability.