Diclofenac (Voltaren, Cataflam) is approved for use in rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, dysmenorrhea, and topically for the treatment treatment of ocular inflammation and actinic keratosis. Diclofenac exhibits approximately equal selectivity for COX-1 and COX-2. The most common adverse reactions are GI disturbances and headache.A reversible elevation of serum transaminases occurs in 15% of patients.
Diclofenac Acid is a non-steroidal anti-inflammatory drug (NSAID) synthesized via chlorination of diethylamine and subsequent coupling. It serves as the active pharmaceutical ingredient (API). Molecular Formula: C14H11Cl2NO2; CAS No.: 15307-86-5.
Strictly contraindicated for patients with severe renal impairment or active peptic ulcers. Store in cool, dry conditions below 25°C to prevent hydrolysis. Personnel must wear PPE to avoid skin contact and inhalation of dust particles.